Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications.
Identifieur interne : 000973 ( Main/Exploration ); précédent : 000972; suivant : 000974Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications.
Auteurs : Florent Baicry [France] ; Pierrick Le Borgne [France] ; Thibaut Fabacher [France] ; Martin Behr [France] ; Elena Laura Lemaitre [France] ; Paul-Albert Gayol [France] ; Sébastien Harscoat [France] ; Nirvan Issur [France] ; Sabrina Garnier-Kepka [France] ; Mickael Ohana [France] ; Pascal Bilbault [France] ; Mathieu Oberlin [France]Source :
- Journal of clinical medicine [ 2077-0383 ] ; 2020.
Abstract
The sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) has been questioned due to negative results in some patients who were strongly suspected of having coronavirus disease 2019 (COVID-19). The aim of our study was to analyze the prognosis of infected patients with initial negative RT-PCR in the emergency department (ED) during the COVID-19 outbreak. This study included two cohorts of adult inpatients admitted into the ED. All patients who were suspected to be infected with SARS-CoV-2 and who underwent a typical chest CT imaging were included. Thus, we studied two distinct cohorts: patients with positive RT-PCR (PCR+) and those with negative initial RT-PCR (PCR-). The data were analyzed using Bayesian methods. We included 66 patients in the PCR- group and 198 in the PCR+ group. The baseline characteristics did not differ except in terms of a proportion of lower chronic respiratory disease in the PCR- group. We noted a less severe clinical presentation in the PCR- group (lower respiratory rate, lower oxygen need and mechanical ventilation requirement). Hospital mortality (9.1% vs. 9.6%) did not differ between the two groups. Despite an initially less serious clinical presentation, the mortality of patients infected by SARS-CoV-2 with a negative RT-PCR did not differ from those with positive RT-PCR.
DOI: 10.3390/jcm9093014
PubMed: 32962092
Affiliations:
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xml:lang="en">Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications.</title><author><name sortKey="Baicry, Florent" sort="Baicry, Florent" uniqKey="Baicry F" first="Florent" last="Baicry">Florent Baicry</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Le Borgne, Pierrick" sort="Le Borgne, Pierrick" uniqKey="Le Borgne P" first="Pierrick" last="Le Borgne">Pierrick Le Borgne</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), Fédération de Médecine Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), Fédération de Médecine Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Fabacher, Thibaut" sort="Fabacher, Thibaut" uniqKey="Fabacher T" first="Thibaut" last="Fabacher">Thibaut Fabacher</name><affiliation wicri:level="4"><nlm:affiliation>ICube, équipe IMAGeS, UMR7357, Université de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ICube, équipe IMAGeS, UMR7357, Université de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName><orgName type="university">Université de Strasbourg</orgName></affiliation></author><author><name sortKey="Behr, Martin" sort="Behr, Martin" uniqKey="Behr M" first="Martin" last="Behr">Martin Behr</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Lemaitre, Elena Laura" sort="Lemaitre, Elena Laura" uniqKey="Lemaitre E" first="Elena Laura" last="Lemaitre">Elena Laura Lemaitre</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Gayol, Paul Albert" sort="Gayol, Paul Albert" uniqKey="Gayol P" first="Paul-Albert" last="Gayol">Paul-Albert Gayol</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Harscoat, Sebastien" sort="Harscoat, Sebastien" uniqKey="Harscoat S" first="Sébastien" last="Harscoat">Sébastien Harscoat</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Issur, Nirvan" sort="Issur, Nirvan" uniqKey="Issur N" first="Nirvan" last="Issur">Nirvan Issur</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Garnier Kepka, Sabrina" sort="Garnier Kepka, Sabrina" uniqKey="Garnier Kepka S" first="Sabrina" last="Garnier-Kepka">Sabrina Garnier-Kepka</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ohana, Mickael" sort="Ohana, Mickael" uniqKey="Ohana M" first="Mickael" last="Ohana">Mickael Ohana</name><affiliation wicri:level="3"><nlm:affiliation>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Bilbault, Pascal" sort="Bilbault, Pascal" uniqKey="Bilbault P" first="Pascal" last="Bilbault">Pascal Bilbault</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), Fédération de Médecine Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), Fédération de Médecine Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Oberlin, Mathieu" sort="Oberlin, Mathieu" uniqKey="Oberlin M" first="Mathieu" last="Oberlin">Mathieu Oberlin</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>HuManiS Laboratory (EA7308), Ecole de Management (EM), University of Strasbourg, 67000 Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>HuManiS Laboratory (EA7308), Ecole de Management (EM), University of Strasbourg, 67000 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of clinical medicine</title><idno type="ISSN">2077-0383</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) has been questioned due to negative results in some patients who were strongly suspected of having coronavirus disease 2019 (COVID-19). The aim of our study was to analyze the prognosis of infected patients with initial negative RT-PCR in the emergency department (ED) during the COVID-19 outbreak. This study included two cohorts of adult inpatients admitted into the ED. All patients who were suspected to be infected with SARS-CoV-2 and who underwent a typical chest CT imaging were included. Thus, we studied two distinct cohorts: patients with positive RT-PCR (PCR+) and those with negative initial RT-PCR (PCR-). The data were analyzed using Bayesian methods. We included 66 patients in the PCR- group and 198 in the PCR+ group. The baseline characteristics did not differ except in terms of a proportion of lower chronic respiratory disease in the PCR- group. We noted a less severe clinical presentation in the PCR- group (lower respiratory rate, lower oxygen need and mechanical ventilation requirement). Hospital mortality (9.1% vs. 9.6%) did not differ between the two groups. Despite an initially less serious clinical presentation, the mortality of patients infected by SARS-CoV-2 with a negative RT-PCR did not differ from those with positive RT-PCR.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32962092</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>24</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2077-0383</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>18</Day></PubDate></JournalIssue><Title>Journal of clinical medicine</Title><ISOAbbreviation>J Clin Med</ISOAbbreviation></Journal><ArticleTitle>Patients with Initial Negative RT-PCR and Typical Imaging of COVID-19: Clinical Implications.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E3014</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/jcm9093014</ELocationID><Abstract><AbstractText>The sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) has been questioned due to negative results in some patients who were strongly suspected of having coronavirus disease 2019 (COVID-19). The aim of our study was to analyze the prognosis of infected patients with initial negative RT-PCR in the emergency department (ED) during the COVID-19 outbreak. This study included two cohorts of adult inpatients admitted into the ED. All patients who were suspected to be infected with SARS-CoV-2 and who underwent a typical chest CT imaging were included. Thus, we studied two distinct cohorts: patients with positive RT-PCR (PCR+) and those with negative initial RT-PCR (PCR-). The data were analyzed using Bayesian methods. We included 66 patients in the PCR- group and 198 in the PCR+ group. The baseline characteristics did not differ except in terms of a proportion of lower chronic respiratory disease in the PCR- group. We noted a less severe clinical presentation in the PCR- group (lower respiratory rate, lower oxygen need and mechanical ventilation requirement). Hospital mortality (9.1% vs. 9.6%) did not differ between the two groups. Despite an initially less serious clinical presentation, the mortality of patients infected by SARS-CoV-2 with a negative RT-PCR did not differ from those with positive RT-PCR.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baicry</LastName><ForeName>Florent</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0002-0534-0122</Identifier><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Borgne</LastName><ForeName>Pierrick</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0001-9141-6439</Identifier><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), Fédération de Médecine Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fabacher</LastName><ForeName>Thibaut</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>ICube, équipe IMAGeS, UMR7357, Université de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Behr</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemaitre</LastName><ForeName>Elena Laura</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gayol</LastName><ForeName>Paul-Albert</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harscoat</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Issur</LastName><ForeName>Nirvan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garnier-Kepka</LastName><ForeName>Sabrina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ohana</LastName><ForeName>Mickael</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0003-0179-5784</Identifier><AffiliationInfo><Affiliation>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bilbault</LastName><ForeName>Pascal</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0003-0904-4600</Identifier><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), Fédération de Médecine Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oberlin</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-3419-5307</Identifier><AffiliationInfo><Affiliation>Emergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>HuManiS Laboratory (EA7308), Ecole de Management (EM), University of Strasbourg, 67000 Strasbourg, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>J Clin Med</MedlineTA><NlmUniqueID>101606588</NlmUniqueID><ISSNLinking>2077-0383</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bayesian analysis</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">clinical management</Keyword><Keyword MajorTopicYN="N">reverse transcriptase polymerase chain reaction</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>09</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>23</Day><Hour>1</Hour><Minute>3</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32962092</ArticleId><ArticleId IdType="pii">jcm9093014</ArticleId><ArticleId IdType="doi">10.3390/jcm9093014</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li></region><settlement><li>Strasbourg</li></settlement><orgName><li>Université de Strasbourg</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Baicry, Florent" sort="Baicry, Florent" uniqKey="Baicry F" first="Florent" last="Baicry">Florent Baicry</name></region><name sortKey="Behr, Martin" sort="Behr, Martin" uniqKey="Behr M" first="Martin" last="Behr">Martin Behr</name><name sortKey="Bilbault, Pascal" sort="Bilbault, Pascal" uniqKey="Bilbault P" first="Pascal" last="Bilbault">Pascal Bilbault</name><name sortKey="Bilbault, Pascal" sort="Bilbault, Pascal" uniqKey="Bilbault P" first="Pascal" last="Bilbault">Pascal Bilbault</name><name sortKey="Fabacher, Thibaut" sort="Fabacher, Thibaut" uniqKey="Fabacher T" first="Thibaut" last="Fabacher">Thibaut Fabacher</name><name sortKey="Garnier Kepka, Sabrina" sort="Garnier Kepka, Sabrina" uniqKey="Garnier Kepka S" first="Sabrina" last="Garnier-Kepka">Sabrina Garnier-Kepka</name><name sortKey="Gayol, Paul Albert" sort="Gayol, Paul Albert" uniqKey="Gayol P" first="Paul-Albert" last="Gayol">Paul-Albert Gayol</name><name sortKey="Harscoat, Sebastien" sort="Harscoat, Sebastien" uniqKey="Harscoat S" first="Sébastien" last="Harscoat">Sébastien Harscoat</name><name sortKey="Issur, Nirvan" sort="Issur, Nirvan" uniqKey="Issur N" first="Nirvan" last="Issur">Nirvan Issur</name><name sortKey="Le Borgne, Pierrick" sort="Le Borgne, Pierrick" uniqKey="Le Borgne P" first="Pierrick" last="Le Borgne">Pierrick Le Borgne</name><name sortKey="Le Borgne, Pierrick" sort="Le Borgne, Pierrick" uniqKey="Le Borgne P" first="Pierrick" last="Le Borgne">Pierrick Le Borgne</name><name sortKey="Lemaitre, Elena Laura" sort="Lemaitre, Elena Laura" uniqKey="Lemaitre E" first="Elena Laura" last="Lemaitre">Elena Laura Lemaitre</name><name sortKey="Oberlin, Mathieu" sort="Oberlin, Mathieu" uniqKey="Oberlin M" first="Mathieu" last="Oberlin">Mathieu Oberlin</name><name sortKey="Oberlin, Mathieu" sort="Oberlin, Mathieu" uniqKey="Oberlin M" first="Mathieu" last="Oberlin">Mathieu Oberlin</name><name sortKey="Ohana, Mickael" sort="Ohana, Mickael" uniqKey="Ohana M" first="Mickael" last="Ohana">Mickael Ohana</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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